2020Journal Article ER2 Auteurs : Ly, Océane; Monchau, Francine; Rémond, Sébastien; Lors, Christine; Jouanneaux, Alain; Debarre, Étienne; Damidot, Denis Optimization of the formulation of an original hydrogel-based bone cement using a mixture design In: Journal of the Mechanical Behavior of Biomedical Materials, vol. 110, pp. 103886, 2020, ISSN: 1751-6161, (ACL). Abstract | Links @article{LY2020103886,
title = {Optimization of the formulation of an original hydrogel-based bone cement using a mixture design},
author = {Océane Ly and Francine Monchau and Sébastien Rémond and Christine Lors and Alain Jouanneaux and Étienne Debarre and Denis Damidot},
url = {https://www.sciencedirect.com/science/article/pii/S1751616120304409},
doi = {https://doi.org/10.1016/j.jmbbm.2020.103886},
issn = {1751-6161},
year = {2020},
date = {2020-01-01},
journal = {Journal of the Mechanical Behavior of Biomedical Materials},
volume = {110},
pages = {103886},
abstract = {Highly swelling polymers, i.e. superabsorbent hydrogels, are hydrophilic, three dimensional networks that can easily absorb a significant amount water, fluid or drug. They are widely used in various applications such as foods, cosmetics, and medical devices. Bone cements are used in orthopaedics as a filling biomaterial or as a grout enhancing the embedding of a prosthesis into bone and fixation is achieved by mechanical interlock with metal or bone surfaces. Recently, hydrophilic bone cements have attracted the attention for bone tissue-engineering applications. Here a bone cement containing an acrylic hydrogel (HEMA) as a liquid phase and a blend of corn starch, cellulose acetate and bioceramic filler as a solid phase is investigated by means of a mixture design which is a special topic within statistical Design of Experiments (DoE). Output variables of interest, complex shear modulus, compressive modulus and swelling rate related to rheological, mechanical and swelling properties respectively, are measured for each cement formulation. Applying the mixture design strategy enables to assess the impact of the three powder components on each variable of interest and to determine the optimal formulation in order to achieve the required properties of this HEMA-based bone cement, especially the rheology adapted to the desired clinical application, but also appropriate mechanical and swelling properties.},
note = {ACL},
keywords = {ER2},
pubstate = {published},
tppubtype = {article}
}
Highly swelling polymers, i.e. superabsorbent hydrogels, are hydrophilic, three dimensional networks that can easily absorb a significant amount water, fluid or drug. They are widely used in various applications such as foods, cosmetics, and medical devices. Bone cements are used in orthopaedics as a filling biomaterial or as a grout enhancing the embedding of a prosthesis into bone and fixation is achieved by mechanical interlock with metal or bone surfaces. Recently, hydrophilic bone cements have attracted the attention for bone tissue-engineering applications. Here a bone cement containing an acrylic hydrogel (HEMA) as a liquid phase and a blend of corn starch, cellulose acetate and bioceramic filler as a solid phase is investigated by means of a mixture design which is a special topic within statistical Design of Experiments (DoE). Output variables of interest, complex shear modulus, compressive modulus and swelling rate related to rheological, mechanical and swelling properties respectively, are measured for each cement formulation. Applying the mixture design strategy enables to assess the impact of the three powder components on each variable of interest and to determine the optimal formulation in order to achieve the required properties of this HEMA-based bone cement, especially the rheology adapted to the desired clinical application, but also appropriate mechanical and swelling properties. |
2018Journal Article ER2 Auteurs : Nguyen, T -K; Carpentier, Olivier; Monchau, Francine; Chai, F; Hornez, J C; Hivart, Philippe Numerical optimization of cell colonization modelling inside scaffold for perfusion bioreactor: A multiscale model In: Medical Engineering and Physics, vol. 57, pp. 40-50, 2018, (cited By 4). Links @article{Nguyen201840,
title = {Numerical optimization of cell colonization modelling inside scaffold for perfusion bioreactor: A multiscale model},
author = {T -K Nguyen and Olivier Carpentier and Francine Monchau and F Chai and J C Hornez and Philippe Hivart},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046702227&doi=10.1016%2fj.medengphy.2018.04.012&partnerID=40&md5=432916873ff02303a4ae60d059a30466},
doi = {10.1016/j.medengphy.2018.04.012},
year = {2018},
date = {2018-01-01},
journal = {Medical Engineering and Physics},
volume = {57},
pages = {40-50},
note = {cited By 4},
keywords = {ER2},
pubstate = {published},
tppubtype = {article}
}
|
2016Journal Article ER2 Auteurs : Aubrun-Fillâtre, Celine; Monchau, Francine; Hivart, Philippe Acrylic bone cement and starch: Botanical variety impact on curing parameters and degradability In: Materials Science and Engineering: C, vol. 69, pp. 1328-1334, 2016, ISSN: 0928-4931, (ACL). Abstract | Links @article{AUBRUNFILLATRE20161328,
title = {Acrylic bone cement and starch: Botanical variety impact on curing parameters and degradability},
author = {Celine Aubrun-Fillâtre and Francine Monchau and Philippe Hivart},
url = {https://www.sciencedirect.com/science/article/pii/S0928493116307883},
doi = {10.1016/j.msec.2016.08.023},
issn = {0928-4931},
year = {2016},
date = {2016-01-01},
journal = {Materials Science and Engineering: C},
volume = {69},
pages = {1328-1334},
abstract = {Acrylic bone cements are a conventional solution to heal bone defects. Starch is often added to the cement to improve its degradability and resorbability. The most used botanical variety is corn starch; few studies or applications deal with other varieties. This study focuses on classical formulations based on 2-hydroxyethylmethacrylate but incorporating different starches: waxy maize, corn, amylo maize, wheat, pea or potato, with or without enzyme (α-amylase). A thermocouple is used to determine the curing parameters: setting time and maximal temperature. The water uptake depends on the cement immersion time in a biological fluid and it is studied through sample mass variation analysis. The weight loss is determined after immersion (function of the time) and drying. Starch botanical variety and enzyme presence do not impact curing parameters and water uptake but strongly influence degradability. Water uptake involves advantageous swelling in situ filling the defect. This study shows that starch accessibility by the enzyme explains this impact. Grain spatial configuration, specific surface area and starch distribution in cement give a complementary explanation of the well-known influence of the ratio amylopectin/amylose. Acrylic cements incorporating starch can be classified according to their degradability.},
note = {ACL},
keywords = {ER2},
pubstate = {published},
tppubtype = {article}
}
Acrylic bone cements are a conventional solution to heal bone defects. Starch is often added to the cement to improve its degradability and resorbability. The most used botanical variety is corn starch; few studies or applications deal with other varieties. This study focuses on classical formulations based on 2-hydroxyethylmethacrylate but incorporating different starches: waxy maize, corn, amylo maize, wheat, pea or potato, with or without enzyme (α-amylase). A thermocouple is used to determine the curing parameters: setting time and maximal temperature. The water uptake depends on the cement immersion time in a biological fluid and it is studied through sample mass variation analysis. The weight loss is determined after immersion (function of the time) and drying. Starch botanical variety and enzyme presence do not impact curing parameters and water uptake but strongly influence degradability. Water uptake involves advantageous swelling in situ filling the defect. This study shows that starch accessibility by the enzyme explains this impact. Grain spatial configuration, specific surface area and starch distribution in cement give a complementary explanation of the well-known influence of the ratio amylopectin/amylose. Acrylic cements incorporating starch can be classified according to their degradability. |
2016Journal Article ER3 Auteurs : Chartier, Thierry; Carpentier, Olivier; Genestie, Benoit; Hornez, J-C.; Monchau, Francine Numerical and ex vivo studies of a bioprobe developed for laser-induced thermotherapy (LITT) in contact with liver tissue In: Medical Engineering & Physics, vol. 38, no. 8, pp. 733-740, 2016, (ACL). Links @article{chartier:hal-03276066,
title = {Numerical and ex vivo studies of a bioprobe developed for laser-induced thermotherapy (LITT) in contact with liver tissue},
author = {Thierry Chartier and Olivier Carpentier and Benoit Genestie and J-C. Hornez and Francine Monchau},
url = {https://hal-unilim.archives-ouvertes.fr/hal-03276066},
doi = {10.1016/j.medengphy.2016.04.024},
year = {2016},
date = {2016-08-01},
urldate = {2016-08-01},
journal = {Medical Engineering & Physics},
volume = {38},
number = {8},
pages = {733-740},
publisher = {Elsevier},
note = {ACL},
keywords = {ER3},
pubstate = {published},
tppubtype = {article}
}
|
2013Journal Article ER2 Auteurs : Monchau, Francine; Hivart, Philippe; Genestie, Benoit; Chai, F; Descamps, M; Hildebrand, H F Calcite as a bone substitute. Comparison with hydroxyapatite and tricalcium phosphate with regard to the osteoblastic activity In: Materials Science and Engineering: C, vol. 33, no. 1, pp. 490–498, 2013. Links @article{Monchau2013,
title = {Calcite as a bone substitute. Comparison with hydroxyapatite and tricalcium phosphate with regard to the osteoblastic activity},
author = {Francine Monchau and Philippe Hivart and Benoit Genestie and F Chai and M Descamps and H F Hildebrand},
doi = {10.1016/j.msec.2012.09.019},
year = {2013},
date = {2013-01-01},
journal = {Materials Science and Engineering: C},
volume = {33},
number = {1},
pages = {490--498},
publisher = {Elsevier BV},
keywords = {ER2},
pubstate = {published},
tppubtype = {article}
}
|
2012Journal Article ER2 Auteurs : Duchatel-Crépy, Lucie; Monchau, Francine; Chai, Feng; é, Gw; Hivart, Philippe; Hildebrand, Hartmut F; Martin, Patrick; Joly, Nicolas Evaluation of a bio-based hydrophobic cellulose laurate film as biomaterial-Study on biodegradation and cytocompatibility In: Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 100B, no. 4, pp. 1000–1008, 2012. Links @article{Crepy2012,
title = {Evaluation of a bio-based hydrophobic cellulose laurate film as biomaterial-Study on biodegradation and cytocompatibility},
author = {Lucie Duchatel-Crépy and Francine Monchau and Feng Chai and Gw é and Philippe Hivart and Hartmut F Hildebrand and Patrick Martin and Nicolas Joly},
doi = {10.1002/jbm.b.32665},
year = {2012},
date = {2012-02-01},
journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials},
volume = {100B},
number = {4},
pages = {1000--1008},
publisher = {Wiley},
keywords = {ER2},
pubstate = {published},
tppubtype = {article}
}
|
2008Journal Article ER4 Auteurs : Descamps, Michel; Duhoo, T; Monchau, Francine; Lu, J; Hardouin, P; Hornez, J C; Leriche, A Manufacture of macroporous β-tricalcium phosphate bioceramics In: Journal of the European Ceramic Society, vol. 28, no. 1, pp. 149-157, 2008, (ACL). Abstract @article{Descamps2008b,
title = {Manufacture of macroporous β-tricalcium phosphate bioceramics},
author = {Michel Descamps and T Duhoo and Francine Monchau and J Lu and P Hardouin and J C Hornez and A Leriche},
year = {2008},
date = {2008-01-01},
journal = {Journal of the European Ceramic Society},
volume = {28},
number = {1},
pages = {149-157},
abstract = {Β-tricalcium phosphate (β-tcp) macroporous ceramics were produced by a new manufacturing procedure. an organic skeleton constituted of polymethylmethacrylate balls (pmma) is carried by a chemical forming treatment. this treatment consists to establish a connection between pmma balls by a chemical superficial dissolution of the individual beads. this reaction is accompanied of significant shrinkage of the organic skeleton which is correlated with the interconnection size between beads. an empirical relation and a geometrical model, based on a theoretical arrangement of spheres of uniform sizes, were developed to determine the necessary shrinkage of the organic skeleton to obtain a desired interconnection size. pmma skeleton is impregnated by using an aqueous suspension of β-tcp, after drying, the ceramic/polymeric composite undergoes the traditional steps of debinding and sintering to obtain finished material. this process allows a total control of the porous architecture of the part (sizes of pores and interconnections) and also to perform materials with very varied forms and dimensions with specific properties as a gradient of pore sizes or a gradient of the interconnection sizes.},
note = {ACL},
keywords = {ER4},
pubstate = {published},
tppubtype = {article}
}
Β-tricalcium phosphate (β-tcp) macroporous ceramics were produced by a new manufacturing procedure. an organic skeleton constituted of polymethylmethacrylate balls (pmma) is carried by a chemical forming treatment. this treatment consists to establish a connection between pmma balls by a chemical superficial dissolution of the individual beads. this reaction is accompanied of significant shrinkage of the organic skeleton which is correlated with the interconnection size between beads. an empirical relation and a geometrical model, based on a theoretical arrangement of spheres of uniform sizes, were developed to determine the necessary shrinkage of the organic skeleton to obtain a desired interconnection size. pmma skeleton is impregnated by using an aqueous suspension of β-tcp, after drying, the ceramic/polymeric composite undergoes the traditional steps of debinding and sintering to obtain finished material. this process allows a total control of the porous architecture of the part (sizes of pores and interconnections) and also to perform materials with very varied forms and dimensions with specific properties as a gradient of pore sizes or a gradient of the interconnection sizes. |
2008Journal Article ER2 Auteurs : DESCAMPS, M; DUHOO, T; Monchau, Francine; LU, J; HARDOUIN, P; HORNEZ, J C; LERICHE, A Manufacture of macroporous ?-tricalcium phosphate bioceramics, JEurop Ceramic Soc,2008, 28(1), 149-157. In: 2008, (ACL). @article{DESCAMPS2008b,
title = {Manufacture of macroporous ?-tricalcium phosphate bioceramics, JEurop Ceramic Soc,2008, 28(1), 149-157.},
author = {M DESCAMPS and T DUHOO and Francine Monchau and J LU and P HARDOUIN and J C HORNEZ and A LERICHE},
year = {2008},
date = {2008-01-01},
note = {ACL},
keywords = {ER2},
pubstate = {published},
tppubtype = {article}
}
|
